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Issue 5, 2011
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Borate esters as convenient reagents for direct amidation of carboxylic acids and transamidation of primary amides

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Abstract

Simple borates serve as effective promoters for amide bond formation with a variety of carboxylic acids and amines. With trimethyl or tris(2,2,2-trifluoroethyl) borate, amides are obtained in good to excellent yield and high purity after a simple work-up procedure. Tris(2,2,2-trifluoroethyl) borate can also be used for the straightforward conversion of primary amides to secondary amidesvia transamidation.

Graphical abstract: Borate esters as convenient reagents for direct amidation of carboxylic acids and transamidation of primary amides

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Publication details

The article was received on 23 Nov 2010, accepted on 14 Dec 2010 and first published on 16 Dec 2010


Article type: Communication
DOI: 10.1039/C0OB01069C
Citation: Org. Biomol. Chem., 2011,9, 1320-1323
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    Borate esters as convenient reagents for direct amidation of carboxylic acids and transamidation of primary amides

    P. Starkov and T. D. Sheppard, Org. Biomol. Chem., 2011, 9, 1320
    DOI: 10.1039/C0OB01069C

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