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Department of Chemistry, University College London, Christopher Ingold Laboratories, 20 Gordon Street, London, U.K.
E-mail: tom.sheppard@ucl.ac.uk
; Fax: +44 (0)20 7679 7463
; Tel: +44 (0)20 7679 2467
Org. Biomol. Chem., 2011,9, 1320-1323
DOI:
10.1039/C0OB01069C
Received
23 Nov 2010,
Accepted
14 Dec 2010
First published online
16 Dec 2010
Simple borates serve as effective promoters for amide bond formation with a variety of carboxylic acids and amines. With trimethyl or tris(2,2,2-trifluoroethyl) borate, amides are obtained in good to excellent yield and high purity after a simple work-up procedure. Tris(2,2,2-trifluoroethyl) borate can also be used for the straightforward conversion of primary amides to secondary amidesvia transamidation.
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Organic & Biomolecular Chemistry
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