Issue 23, 2010
From the journal:

Organic & Biomolecular Chemistry

Preparation of arylsulfonyl chlorides by chlorosulfonylation of in situ generated diazonium salts using a continuous flow reactor†

Laia Malet-Sanz,*ab   Julia Madrzak,b   Steven V. Leya  and  Ian R. Baxendalea  

* Corresponding authors

a Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK
E-mail: theitc@ch.cam.ac.uk

b World Wide Medicinal Chemistry, Pfizer Global Research and Development, Ramsgate Road, Sandwich, UK
E-mail: laia.malet@pfizer.com

Abstract

A new flow procedure for the preparation of arylsulfonyl chlorides from aniline starting materials is described. The reaction conditions are mild, requiring no added acid and are amenable to continuous flow processing, in a safe, easily scalable and less labour intensive way than the corresponding batch method.

Graphical abstract: Preparation of arylsulfonyl chlorides by chlorosulfonylation of in situ generated diazonium salts using a continuous flow reactor

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Article information

DOI
https://doi.org/10.1039/C0OB00450B
Article type
Paper
Submitted
19 Jul 2010
Accepted
27 Aug 2010
First published
27 Sep 2010

Org. Biomol. Chem., 2010,8, 5324-5332

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Preparation of arylsulfonyl chlorides by chlorosulfonylation of in situ generated diazonium salts using a continuous flow reactor

L. Malet-Sanz, J. Madrzak, S. V. Ley and I. R. Baxendale, Org. Biomol. Chem., 2010, 8, 5324 DOI: 10.1039/C0OB00450B

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