Issue 11, 2010
From the journal:

Organic & Biomolecular Chemistry

Organocatalytic kinetic resolution via intramolecular aldol reactions: Enantioselective synthesis of both enantiomers of chiral cyclohexenones†

Liujuan Chen,a   Sanzhong Luo,*a   Jiuyuan Li,a   Xin Lia  and  Jin-Pei Cheng*a  

* Corresponding authors

a Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Science, Beijing, China
E-mail: luosz@iccas.ac.cn
Fax: +86-10-62554449
Tel: +86-10-62554446

Abstract

Kinetic resolution of 6-aryl-2,6-hexanediones was achieved with chiral secondary amine catalyzed intramolecular aldolization. The current kinetic resolution protocol enables the synthesis of both enantiomers of cyclohexenones with moderate to good enantioselectivity.

Graphical abstract: Organocatalytic kinetic resolution via intramolecular aldol reactions: Enantioselective synthesis of both enantiomers of chiral cyclohexenones

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Article information

DOI
https://doi.org/10.1039/B927343C
Article type
Paper
Submitted
07 Jan 2010
Accepted
17 Mar 2010
First published
01 Apr 2010

Org. Biomol. Chem., 2010,8, 2627-2632

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Organocatalytic kinetic resolution via intramolecular aldol reactions: Enantioselective synthesis of both enantiomers of chiral cyclohexenones

L. Chen, S. Luo, J. Li, X. Li and J. Cheng, Org. Biomol. Chem., 2010, 8, 2627 DOI: 10.1039/B927343C

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