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Département de Chimie Moléculaire, UMR-5250, ICMG FR-2607, CNRS, Université Joseph Fourier, BP-53, Grenoble, France
E-mail: Veronique.Blandin@ujf-grenoble.fr
Org. Biomol. Chem., 2010,8, 864-872
DOI:
10.1039/B918612C
Received
08 Sep 2009,
Accepted
11 Nov 2009
First published online
22 Dec 2009
The resolution of chiral nitrones viaderivatization of hydroxylamines was applied to MiPNO, a new, stable, easily prepared chiral cyclic nitrone. The application of MiPNO in totally regio- and diastereo-selective 1,3-dipolar cycloaddition reactions provides an expeditious enantioselective access to unusual γ-hydroxy α-amino acids.
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Organic & Biomolecular Chemistry
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