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Issue 12, 2010
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A novel class of potential prion drugs: preliminary in vitro and in vivo data for multilayer coated gold nanoparticles

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Abstract

Gold nanoparticles coated with oppositely charged polyelectrolytes, such as polyallylamine hydrochloride and polystyrenesulfonate, were examined for potential inhibition of prion protein aggregation and prion (PrPSc) conversion and replication. Different coatings, finishing with a positive or negative layer, were tested, and different numbers of layers were investigated for their ability to interact and reduce the accumulation of PrPSc in scrapie prion infected ScGT1 and ScN2a cells. The particles efficiently hampered the accumulation of PrPSc in ScN2a cells and showed curing effects on ScGT1 cells with a nanoparticle concentration in the picomolar range. Finally, incubation periods of prion-infected mice treated with nanomolar concentrations of gold nanoparticles were significantly longer compared to untreated controls.

Graphical abstract: A novel class of potential prion drugs: preliminary in vitro and in vivo data for multilayer coated gold nanoparticles

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Publication details

The article was received on 30 Jul 2010, accepted on 02 Sep 2010 and first published on 14 Oct 2010


Article type: Paper
DOI: 10.1039/C0NR00551G
Citation: Nanoscale, 2010,2, 2724-2732
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    A novel class of potential prion drugs: preliminary in vitro and in vivo data for multilayer coated gold nanoparticles

    H. N. Ai Tran, F. Sousa, F. Moda, S. Mandal, M. Chanana, C. Vimercati, M. Morbin, S. Krol, F. Tagliavini and G. Legname, Nanoscale, 2010, 2, 2724
    DOI: 10.1039/C0NR00551G

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