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Issue 12, 2010
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Active targeting of cancer cells using folic acid-conjugated platinum nanoparticles

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Abstract

Interaction of nanoparticles with human cells is an interesting topic for understanding toxicity and developing potential drug candidates. Water soluble platinum nanoparticles were synthesized via reduction of hexachloroplatinic acid using sodium borohydride in the presence of capping agents. The bioactivity of folic acid and poly(vinyl pyrrolidone) capped platinum nanoparticles (Pt-nps) has been investigated using commercially available cell lines. In the cell viability experiments, PVP-capped nanoparticles were found to be less toxic (>80% viability), whereas, folic acid-capped platinum nanoparticles showed a reduced viability down to 24% after 72 h of exposure at a concentration of 100 μg ml−1 for MCF7 breast cancer cells. Such toxicity, combined with the possibility to incorporate functional organic molecules as capping agents, can be used for developing new drug candidates.

Graphical abstract: Active targeting of cancer cells using folic acid-conjugated platinum nanoparticles

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Publication details

The article was received on 22 Mar 2010, accepted on 02 Aug 2010 and first published on 11 Oct 2010


Article type: Paper
DOI: 10.1039/C0NR00204F
Citation: Nanoscale, 2010,2, 2607-2613
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    Active targeting of cancer cells using folic acid-conjugated platinum nanoparticles

    Y. Teow and S. Valiyaveettil, Nanoscale, 2010, 2, 2607
    DOI: 10.1039/C0NR00204F

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