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Issue 10, 2010
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Water soluble nanoporous nanoparticle for in vivo targeted drug delivery and controlled release in B cells tumor context

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Abstract

Multitasking nanoparticles are gaining great attention for smart drug delivery systems. The exploration of the nano-scale opens new concrete opportunities for revealing new properties and undiscovered cell–particle interactions. Here we present a biodegradable nanoporous silicon nanoparticle that can be successfully employed for in vivo targeted drug delivery and sustained release. The bare nanoporous nanocarriers can be accurately designed and fabricated with an effective control of porosity, surface chemistry and particle size, up to a few nm. The proposed nanoparticles exhibit several remarkable features including high payload, biodegradability, no toxicity, and multiple loading in water without the need of additional chemical reagents at room temperature. The targeting strategy is based on phage display technology that was successfully used to discover cell surface binding peptide for murine B lymphoma A20 cell line. The peptide used in combination with the nanoporous nanoparticles allows an efficient in vivo targeting, a sustained release and a sensible therapeutic effect.

Graphical abstract: Water soluble nanoporous nanoparticle for in vivo targeted drug delivery and controlled release in B cells tumor context

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Publication details

The article was received on 01 Mar 2010, accepted on 17 Jun 2010 and first published on 07 Sep 2010


Article type: Paper
DOI: 10.1039/C0NR00161A
Citation: Nanoscale, 2010,2, 2230-2236
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    Water soluble nanoporous nanoparticle for in vivo targeted drug delivery and controlled release in B cells tumor context

    F. De Angelis, A. Pujia, C. Falcone, E. Iaccino, C. Palmieri, C. Liberale, F. Mecarini, P. Candeloro, L. Luberto, A. de Laurentiis, G. Das, G. Scala and E. Di Fabrizio, Nanoscale, 2010, 2, 2230
    DOI: 10.1039/C0NR00161A

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