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Issue 6, 2010
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A graphene-enhanced molecular beacon for homogeneous DNA detection

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Abstract

In this work, we report the design of a novel graphene-based molecular beacon (MB) that could sensitively and selectively detect specific DNA sequences. The ability of water-soluble graphene oxide (GO) to differentiated hairpin and dsDNA offered a new approach to detect DNA. We found that the background fluorescence of MB was significantly suppressed in the presence of GO, which increased the signal-to-background ratio, hence the sensitivity. Moreover, the single-mismatch differentiation ability of hairpin DNA was maintained, leading to high selectivity of this new method.

Graphical abstract: A graphene-enhanced molecular beacon for homogeneous DNA detection

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Publication details

The article was received on 10 Dec 2009, accepted on 01 Mar 2010 and first published on 11 May 2010


Article type: Paper
DOI: 10.1039/B9NR00401G
Citation: Nanoscale, 2010,2, 1021-1026
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    A graphene-enhanced molecular beacon for homogeneous DNA detection

    F. Li, Y. Huang, Q. Yang, Z. Zhong, D. Li, L. Wang, S. Song and C. Fan, Nanoscale, 2010, 2, 1021
    DOI: 10.1039/B9NR00401G

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