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Issue 1, 2010
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Electrospun nanofibers for neural tissue engineering

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Biodegradable nanofibers produced by electrospinning represent a new class of promising scaffolds to support nerve regeneration. We begin with a brief discussion on the electrospinning of nanofibers and methods for controlling the structure, porosity, and alignment of the electrospun nanofibers. The methods include control of the nanoscale morphology and microscale alignment of the nanofibers, as well as the fabrication of macroscale, three-dimensional tubular structures. We then highlight recent studies that utilize electrospun nanofibers to manipulate biological processes relevant to nervous tissue regeneration, including stem cell differentiation, guidance of neurite extension, and peripheral nerve injury treatments. The main objective of this feature article is to provide valuable insights into methods for investigating the mechanisms of neurite growth on novel nanofibrous scaffolds and optimization of the nanofiber scaffolds and conduits for repairing peripheral nerve injuries.

Graphical abstract: Electrospun nanofibers for neural tissue engineering

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The article was received on 30 Aug 2009, accepted on 27 Sep 2009 and first published on 27 Oct 2009

Article type: Feature Article
DOI: 10.1039/B9NR00243J
Citation: Nanoscale, 2010,2, 35-44
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    Electrospun nanofibers for neural tissue engineering

    J. Xie, M. R. MacEwan, A. G. Schwartz and Y. Xia, Nanoscale, 2010, 2, 35
    DOI: 10.1039/B9NR00243J

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