Issue 8, 2010
From the journal:

New Journal of Chemistry

Generation of arylzinc reagents through an iodine–zinc exchange reaction promoted by a non-metallic organic superbase†

Hiroshi Naka,*ab   Keisuke Ito,a   Masahiro Ueno,a   Koji Kobayashia  and  Yoshinori Kondo*a  

* Corresponding authors

a Graduate School of Pharmaceutical Sciences, Tohoku University, Aramaki Aza Aoba 6-3, Aoba-ku, Japan
E-mail: ykondo@mail.pharm.tohoku.ac.jp
Fax: +81 22-795-6804
Tel: +81 22-795-6804

b Research Center for Materials Science, Nagoya University, Chikusa, Japan
E-mail: naka.hiroshi@a.mbox.nagoya-u.ac.jp
Fax: +81 52-789-5904
Tel: +81 52-789-5904

Abstract

Functionalized aryl and heteroaryl zinc reagents were prepared from aryl iodides and diethylzinc through t-Bu-P4 base-promoted iodine–zinc exchange reactions. The scope and limitations of this protocol, and several applications for the synthesis of oligoaryls and fused aromatics, are presented.

Graphical abstract: Generation of arylzinc reagents through an iodine–zinc exchange reaction promoted by a non-metallic organic superbase

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Article information

DOI
https://doi.org/10.1039/C0NJ00202J
Article type
Paper
Submitted
16 Mar 2010
Accepted
28 Apr 2010
First published
09 Jun 2010

New J. Chem., 2010,34, 1700-1706

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Generation of arylzinc reagents through an iodine–zinc exchange reaction promoted by a non-metallic organic superbase

H. Naka, K. Ito, M. Ueno, K. Kobayashi and Y. Kondo, New J. Chem., 2010, 34, 1700 DOI: 10.1039/C0NJ00202J

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