Issue 1, 2010
From the journal:

New Journal of Chemistry

DNA photocleavage in anaerobic conditions by a Ru(ii) polypyridyl complex with long wavelength MLCT absorption†

Qian-Xiong Zhou,ab   Wan-Hua Lei,a   Chao Li,a   Yuan-Jun Hou,a   Xue-Song Wang*a  and  Bao-Wen Zhang*a  

* Corresponding authors

a Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, P. R. China
E-mail: xswang@mail.ipc.ac.cn, g203@mail.ipc.ac.cn

b Graduate School of Chinese Academy of Sciences, P. R. China

Abstract

Ru(II) polypyridyl complexes possessing long wavelength absorption and an efficient DNA photocleavage activity exhibit a potential application in photodynamic therapy (PDT). In this article, we reported a Ru(II) polypyridyl complex, [Ru(bpy)2(dpb)]2+ (bpy = 2,2′-bipyridine, dpb = 2,3-bis(2-pyridyl)benzoquinoxaline), that exhibits a very long wavelength 1MLCT absorption, with a maximum at 550 nm, and DNA photocleavage activity in anaerobic conditions in the presence of suitable oxidative quenchers, showing a promising potential application in the PDT of hypoxic tumors.

Graphical abstract: DNA photocleavage in anaerobic conditions by a Ru(ii) polypyridyl complex with long wavelength MLCT absorption

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Article information

DOI
https://doi.org/10.1039/B9NJ00465C
Article type
Paper
Submitted
17 Aug 2009
Accepted
29 Sep 2009
First published
02 Nov 2009

New J. Chem., 2010,34, 137-140

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DNA photocleavage in anaerobic conditions by a Ru(II) polypyridyl complex with long wavelength MLCT absorption

Q. Zhou, W. Lei, C. Li, Y. Hou, X. Wang and B. Zhang, New J. Chem., 2010, 34, 137 DOI: 10.1039/B9NJ00465C

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