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Issue 6, 2010
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Metalloproteomics and metal toxicology of α-synuclein

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Abstract

Significant evidence has been accumulated linking exposure to heavy metals and/or distortion of metal homeostasis with the development of various neurodegenerative diseases. α-Synuclein is known to be involved in pathogenesis of a subset of neurodegenerative diseases collectively known as synucleinopathies. Therefore the interplay between metals, α-synuclein and neurodegeneration has attracted significant attention of researchers. This review discusses some of the aspects of the α-synuclein metalloproteomics and represents the peculiarities and consequences of α-synuclein interaction with various metal ions. Both non-specific and specific binding of this protein to metals is considered together with the analysis of the effects of such interactions on α-synuclein structure and aggregation propensity.

Graphical abstract: Metalloproteomics and metal toxicology of α-synuclein

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Publication details

The article was received on 17 Dec 2009, accepted on 19 Apr 2010 and first published on 13 May 2010


Article type: Critical Review
DOI: 10.1039/B926659C
Citation: Metallomics, 2010,2, 378-392
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    Metalloproteomics and metal toxicology of α-synuclein

    A. Santner and V. N. Uversky, Metallomics, 2010, 2, 378
    DOI: 10.1039/B926659C

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