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Issue 4, 2010
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Hard shell gas-filled contrast enhancement particles for colour Doppler ultrasound imaging of tumors

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Abstract

Hollow hard shell particles of 200 nm and 2 micron diameter with a 10 nm thick porous silica shell have been synthesized using polystyrene templates and a sol–gel process. The template ensures than the hollow particles are monodispersed, while the charged silica surface ensures that they remain suspended in solution for weeks. When filled with perfluorocarbon gas, the particles behave as an efficient contrast agent for colour Doppler ultrasound imaging in human breast tissue. The silica shell provides unique properties compared to conventional soft shell particles employed as ultrasound contrast agents: uniform size control, strong adsorption to tissue and cells immobilizing particles at the tissue injection site, a long imaging lifetime, and a silica surface that can be easily modified with biotargeting ligands or small molecules to adjust the surface charge and polarity.

Graphical abstract: Hard shell gas-filled contrast enhancement particles for colour Doppler ultrasound imaging of tumors

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Publication details

The article was received on 18 Aug 2010, accepted on 19 Aug 2010 and first published on 13 Sep 2010


Article type: Concise Article
DOI: 10.1039/C0MD00139B
Citation: Med. Chem. Commun., 2010,1, 266-270
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    Hard shell gas-filled contrast enhancement particles for colour Doppler ultrasound imaging of tumors

    H. P. Martinez, Y. Kono, S. L. Blair, S. Sandoval, J. Wang-Rodriguez, R. F. Mattrey, A. C. Kummel and W. C. Trogler, Med. Chem. Commun., 2010, 1, 266
    DOI: 10.1039/C0MD00139B

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