Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance upgrade on Thursday 4th of May 2017 from 8.00am to 9.00am (BST).

During this time our websites will be offline temporarily. If you have any questions please use the feedback button on this page. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 4, 2010
Previous Article Next Article

Rapid assembly of potent type II dehydroquinase inhibitors via “Click” chemistry

Author affiliations

Abstract

The rapid synthesis of a library of potent type II dehydroquinase inhibitors is described. Inhibitors were prepared via a key quinate-derived ene-yne intermediate using Cu(I)-catalysed azide-alkyne cycloaddition (CuAAC) chemistry with a variety of aryl- and heteroaryl-azides.

Graphical abstract: Rapid assembly of potent type II dehydroquinase inhibitors via “Click” chemistry

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 02 Jul 2010, accepted on 20 Jul 2010 and first published on 23 Aug 2010


Article type: Concise Article
DOI: 10.1039/C0MD00097C
Citation: Med. Chem. Commun., 2010,1, 271-275
  •   Request permissions

    Rapid assembly of potent type II dehydroquinase inhibitors via “Click” chemistry

    A. T. Tran, K. M. Cergol, W. J. Britton, S. A. Imran Bokhari, M. Ibrahim, A. J. Lapthorn and R. J. Payne, Med. Chem. Commun., 2010, 1, 271
    DOI: 10.1039/C0MD00097C

Search articles by author