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Issue 3, 2010
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Synthesis and biological evaluation of substituted α- and β-2,3-dihydrofuran naphthoquinones as potent anticandidal agents

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Abstract

We report herein, the synthesis and antifungal activity of substituted α- and β-dihydrofuran naphthoquinones. These compounds were prepared from readily available lawsone and olefins in the presence of cerium(IV) ammonium nitrate (CAN) and were then evaluated against the following six strains of Candida (C.): C. albicans, C. krusei, C. parapsilosis, C. kefyr, C. tropicalis and C. dubliniensis. In addition to exhibiting low cytotoxicity, the furan naphthoquinones proved to be active against these fungi, indicating that they are important scaffolds and potential novel antifungal agents.

Graphical abstract: Synthesis and biological evaluation of substituted α- and β-2,3-dihydrofuran naphthoquinones as potent anticandidal agents

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Publication details

The article was received on 07 Jun 2010, accepted on 08 Jul 2010 and first published on 04 Aug 2010


Article type: Concise Article
DOI: 10.1039/C0MD00074D
Citation: Med. Chem. Commun., 2010,1, 229-232
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    Synthesis and biological evaluation of substituted α- and β-2,3-dihydrofuran naphthoquinones as potent anticandidal agents

    C. P. V. Freire, S. B. Ferreira, N. S. M. de Oliveira, A. B. J. Matsuura, I. L. Gama, F. D. C. da Silva, M. C. B. V. de Souza, E. S. Lima and V. F. Ferreira, Med. Chem. Commun., 2010, 1, 229
    DOI: 10.1039/C0MD00074D

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