Issue 1, 2011
From the journal:

MedChemComm

Evaluation of FR901464 analogues in vitro and in vivo

Sami Osman,a   William R. Waud,b   Gregory S. Gorman,c   Billy W. Dayad  and  Kazunori Koide*a  

* Corresponding authors

a Department of Chemistry, University of Pittsburgh, 219 Parkman Avenue, Pittsburgh, Pennsylvania 15260
E-mail: koide@pitt.edu
Fax: +1 412 624 8611
Tel: +1 412 624 8767

b Department of Cancer Therapeutics and Immunology, Southern Research Institute, Birmingham, Alabama

c Department of Toxicology and Bioanalytical Science, Southern Research Institute, Birmingham, Alabama

d Department of Pharmaceutical Sciences, University of Pittsburgh, 3501 Fifth Avenue, Pittsburgh, Pennsylvania 15213

Abstract

This study was designed to determine the in vitro and in vivo antitumor behaviour of three analogues of the natural product FR901464. All analogues demonstrated effective inhibition of cell proliferation. Minimal in vivo antitumor activity was observed, warranting further PK and antitumor efficacy studies.

Graphical abstract: Evaluation of FR901464 analogues in vitro and in vivo

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Article information

DOI
https://doi.org/10.1039/C0MD00179A
Article type
Concise Article
Submitted
07 Oct 2010
Accepted
16 Oct 2010
First published
02 Nov 2010

Med. Chem. Commun., 2011,2, 38-43

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Evaluation of FR901464 analogues in vitro and in vivo

S. Osman, W. R. Waud, G. S. Gorman, B. W. Day and K. Koide, Med. Chem. Commun., 2011, 2, 38 DOI: 10.1039/C0MD00179A

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