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Issue 5, 2010
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Aromatic chloride to nitrile transformation: medicinal and synthetic chemistry

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Abstract

This review highlights the medicinal and synthetic chemistry relevance of replacing an aromatic chloride motif with an aromatic nitrile. We explore the desirable features that this transformation can bring in a drug design sense and the recent synthetic chemistry advances that effect this replacement in a single step.

Graphical abstract: Aromatic chloride to nitrile transformation: medicinal and synthetic chemistry

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Publication details

The article was received on 17 Aug 2010, accepted on 13 Sep 2010 and first published on 11 Oct 2010


Article type: Review Article
DOI: 10.1039/C0MD00135J
Citation: Med. Chem. Commun., 2010,1, 309-318
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    Aromatic chloride to nitrile transformation: medicinal and synthetic chemistry

    L. H. Jones, N. W. Summerhill, N. A. Swain and J. E. Mills, Med. Chem. Commun., 2010, 1, 309
    DOI: 10.1039/C0MD00135J

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