Issue 4, 2010

Selective inhibition of EGFR and VEGFR2 tyrosine kinases controlled by a boronic acid substituent on 4-anilinoquinazolines

Abstract

Boronic acid-containing 4-anilinoquinazolines were synthesized as selective inhibitors of EGFR and VEGFR2 tyrosine kinases. The substituted position of the boronic acid is essential for control of both kinase inhibitions, and the boronic acid substituted at the para position of the aniline moiety exhibited significant inhibition of VEGFR2 tyrosine kinase.

Graphical abstract: Selective inhibition of EGFR and VEGFR2 tyrosine kinases controlled by a boronic acid substituent on 4-anilinoquinazolines

Supplementary files

Article information

Article type
Concise Article
Submitted
20 Jul 2010
Accepted
13 Aug 2010
First published
08 Sep 2010

Med. Chem. Commun., 2010,1, 282-286

Selective inhibition of EGFR and VEGFR2 tyrosine kinases controlled by a boronic acid substituent on 4-anilinoquinazolines

H. Nakamura, R. Horikoshi, T. Usui and H. S. Ban, Med. Chem. Commun., 2010, 1, 282 DOI: 10.1039/C0MD00115E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements