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Issue 11, 2010
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Overcoming glucose repression in mixed sugar fermentation by co-expressing a cellobiose transporter and a β-glucosidase in Saccharomyces cerevisiae

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Abstract

Glucose repression is one of the main limitations in mixed lignocellulosic sugar fermentation for cost-effective production of fuels and chemicals. Here we report a novel strategy to overcome glucose repression by co-expressing a cellobiose transporter and a β-glucosidase in an engineered D-xylose-utilizing Saccharomyces cerevisiae strain. The resulting strain can simultaneously utilize cellobiose and D-xylose for ethanol production.

Graphical abstract: Overcoming glucose repression in mixed sugar fermentation by co-expressing a cellobiose transporter and a β-glucosidase in Saccharomyces cerevisiae

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Publication details

The article was received on 22 Jun 2010, accepted on 19 Aug 2010 and first published on 27 Sep 2010


Article type: Communication
DOI: 10.1039/C0MB00063A
Citation: Mol. BioSyst., 2010,6, 2129-2132
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    Overcoming glucose repression in mixed sugar fermentation by co-expressing a cellobiose transporter and a β-glucosidase in Saccharomyces cerevisiae

    S. Li, J. Du, J. Sun, J. M. Galazka, N. L. Glass, J. H. D. Cate, X. Yang and H. Zhao, Mol. BioSyst., 2010, 6, 2129
    DOI: 10.1039/C0MB00063A

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