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Issue 12, 2010
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System-level strategies for studying the metabolism of Mycobacterium tuberculosis

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Abstract

Despite decades of research many aspects of the biology of Mycobacterium tuberculosis remain unclear and this is reflected in the antiquated tools available to treat and prevent tuberculosis and consequently this disease remains a serious public health problem. Important discoveries linking M. tuberculosis's metabolism and pathogenesis have renewed interest in this area of research. Previous experimental studies were limited to the analysis of individual genes or enzymes whereas recent advances in computational systems biology and high throughput experimental technologies now allow metabolism to be studied on a genome scale. Here we discuss the progress being made in applying system level approaches to studying the metabolism of this important pathogen. The information from these studies will fundamentally change our approach to tuberculosis research and lead to new targets for therapeutic drugs and vaccines.

Graphical abstract: System-level strategies for studying the metabolism of Mycobacterium tuberculosis

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Publication details

The article was received on 01 Mar 2010, accepted on 08 Sep 2010 and first published on 11 Oct 2010


Article type: Review Article
DOI: 10.1039/C003757P
Citation: Mol. BioSyst., 2010,6, 2363-2372
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    System-level strategies for studying the metabolism of Mycobacterium tuberculosis

    D. J. V. Beste and J. McFadden, Mol. BioSyst., 2010, 6, 2363
    DOI: 10.1039/C003757P

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