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Issue 3, 2010
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When ribosomes go bad: diseases of ribosome biogenesis

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Abstract

Ribosomes are vital for cell growth and survival. Until recently, it was believed that mutations in ribosomes or ribosome biogenesis factors would be lethal, due to the essential nature of these complexes. However, in the last few decades, a number of diseases of ribosome biogenesis have been discovered. It remains a challenge in the field to elucidate the molecular mechanisms underlying them.

Graphical abstract: When ribosomes go bad: diseases of ribosome biogenesis

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Publication details

The article was received on 21 Sep 2009, accepted on 22 Oct 2009 and first published on 11 Jan 2010


Article type: Review Article
DOI: 10.1039/B919670F
Citation: Mol. BioSyst., 2010,6, 481-493
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    When ribosomes go bad: diseases of ribosome biogenesis

    E. F. Freed, F. Bleichert, L. M. Dutca and S. J. Baserga, Mol. BioSyst., 2010, 6, 481
    DOI: 10.1039/B919670F

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