Issue 3, 2010
From the journal:

Molecular BioSystems

Interaction and dynamics of the Plasmodium falciparumMTIP–MyoA complex, a key component of the invasion motor in the malaria parasite†

Jemima C. Thomas,a   Judith L. Green,b   Ronald I. Howson,a   Peter Simpson,c   David K. Moss,b   Stephen R. Martin,b   Anthony A. Holder,bd   Ernesto Cota*cd  and  Edward W. Tate*ad  

* Corresponding authors

a Department of Chemistry, Imperial College London, Exhibition Rd., London, UK
E-mail: e.tate@imperial.ac.uk
Fax: +44 (0)20 75941139
Tel: +44 (0)20 75943752

b Division of Parasitology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London, UK

c Division of Molecular Biosciences, Imperial College London, Exhibition Rd., London, UK
E-mail: e.cota@imperial.ac.uk

d Chemical Biology Centre, South Kensington Campus, Imperial College, London, UK

Abstract

The myosin tail domain interacting protein–myosin A (MTIP–MyoA) protein complex is an essential element of the motor driving invasion of red blood cells by the Plasmodium species that cause malaria. Here we report the key determinants of binding at the MTIP/MyoA interface, and the first structural study on the complex in solution using proteinNMR.

Graphical abstract: Interaction and dynamics of the Plasmodium falciparumMTIP–MyoA complex, a key component of the invasion motor in the malaria parasite

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Article information

DOI
https://doi.org/10.1039/B922093C
Article type
Communication
Submitted
22 Oct 2009
Accepted
12 Jan 2010
First published
27 Jan 2010

Mol. BioSyst., 2010,6, 494-498

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Interaction and dynamics of the Plasmodium falciparumMTIP–MyoA complex, a key component of the invasion motor in the malaria parasite

J. C. Thomas, J. L. Green, R. I. Howson, P. Simpson, D. K. Moss, S. R. Martin, A. A. Holder, E. Cota and E. W. Tate, Mol. BioSyst., 2010, 6, 494 DOI: 10.1039/B922093C

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