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Issue 2, 2010
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Complex genetic regulation of proteinglycosylation

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One hundred years have passed since Archibald Garrod postulated the one gene/one enzyme hypothesis. Since then, science has made significant progress and geneticists are now tackling an overwhelming complexity of gene regulation networks that underlie the genetics of complex human diseases. A particularly complex element in the biology of higher organisms is the genetics of proteinglycosylation. Nearly all proteins that appeared after the emergence of multicellular life are glycosylated, but instead of being molded by a single gene, glycan structures are encoded within a network of several hundred glycosyltransferases, glycosidases, transporters, transcription factors and other proteins. In addition, in contrast to the linear structures of DNA and proteins, glycans have multiple branches that make their analysis significantly more challenging. However, recent developments in high throughput HPLC analysis have advanced glycan analysis significantly and it is now possible to address questions about the complex genetics of proteinglycosylation. In this review we present some preliminary insights into this fascinating field.

Graphical abstract: Complex genetic regulation of proteinglycosylation

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The article was received on 29 May 2009, accepted on 21 Sep 2009 and first published on 19 Oct 2009

Article type: Review Article
DOI: 10.1039/B910377E
Citation: Mol. BioSyst., 2010,6, 329-335
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    Complex genetic regulation of proteinglycosylation

    G. Lauc, I. Rudan, H. Campbell and P. M. Rudd, Mol. BioSyst., 2010, 6, 329
    DOI: 10.1039/B910377E

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