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Issue 1, 2010
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Small-molecule modulators of the Sonic Hedgehog signaling pathway

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Abstract

Sonic hedgehog (Shh) is the most widely characterized of the three vertebrate Hedgehoghomologs, and is essential for proper embryonic development. Shh binds to its receptor, Patched (Ptch1), resulting in the de-repression of Smoothened (Smo). This leads to the activation of Gli2, which regulates the transcription of target genes that include Gli1 and Ptch1. Several synthetic and naturally occurring small-molecule modulators of Smo have been discovered. Shh-signalingantagonists that bind to Smo include cyclopamine, SANT1, and Cur-61414. Shh signalingagonists that bind to Smo include the synthetic small molecules purmorphamine and SAG. Small molecules that inhibit Shh signalingdownstream of Smo, GANT58 and GANT61 have also been reported. Robotnikinin inhibits the Shh pathway by directly targeting Shh. Although progress has been made in understanding and modulating Shh signaling, fundamental aspects of Shh signal transduction remain obscure, including the mechanism(s) whereby Ptch1 regulates Smo activity. Small-molecule modulators of Shh signaling provide a means to regulate the activity of a pathway implicated in medulloblastoma, basal cell carcinoma (BCC), pancreatic cancer, prostate cancer and developmental disorders. Several Shh inhibitors have not succeeded in the clinic for unknown reasons, but clinical trials in BCC and pancreatic cancer with the promising Smo antagonists GDC-0449 and IPI-926 are currently underway.

Graphical abstract: Small-molecule modulators of the Sonic Hedgehog signaling pathway

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Publication details

The article was received on 22 May 2009, accepted on 13 Jul 2009 and first published on 27 Aug 2009


Article type: Review Article
DOI: 10.1039/B910196A
Citation: Mol. BioSyst., 2010,6, 44-54
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    Small-molecule modulators of the Sonic Hedgehog signaling pathway

    B. Z. Stanton and L. F. Peng, Mol. BioSyst., 2010, 6, 44
    DOI: 10.1039/B910196A

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