Jump to main content
Jump to site search

Issue 1, 2009
Previous Article Next Article

Comparison of the interactomic networks of different species in terms of accessibility

Author affiliations

Abstract

Proteinprotein interaction networks were investigated in terms of outward accessibility, which quantifies the effectiveness of each protein in accessing other proteins and is related to the internality of nodes. By comparing the accessibility between 144 orthologproteins in yeast and the fruit fly, we found that the accessibility tends to be higher among proteins in the fly than in yeast. In addition, z-scores of the accessibility calculated for different species revealed that the protein networks of less evolved species tend to be more random than those of more evolved species. The accessibility was also used to identify the border of the yeast protein interaction network, which was found to be mainly composed of viable proteins.

Graphical abstract: Comparison of the interactomic networks of different species in terms of accessibility

Back to tab navigation

Publication details

The article was received on 07 Apr 2009, accepted on 24 Aug 2009 and first published on 29 Sep 2009


Article type: Paper
DOI: 10.1039/B906966F
Citation: Mol. BioSyst., 2009,6, 234-240
  •   Request permissions

    Comparison of the interactomic networks of different species in terms of accessibility

    F. A. Rodrigues and L. da Fontoura Costa, Mol. BioSyst., 2009, 6, 234
    DOI: 10.1039/B906966F

Search articles by author

Spotlight

Advertisements