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Issue 24, 2010
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Overview of single-cell analyses: microdevices and applications

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Abstract

Numerous microdevices developed for single-cell analyses have been presented in the last decades. Practical usefulness in biological and clinical settings has become an important focus during the development and implementation of new structures and assays. Single-cell analysis has been applied in intracellular research, gene- and protein content and expression, PCR, cell culture and division, clone formation, differentiation, morphology, lysis, separation, sorting, cytotoxicity and fluorescence screens, antibody secretion, etc. as discussed here along with brief descriptions of the technical devices used for the studies, e.g. well-, trap-, pattern-, and droplet-based structures. This review aims to serve as an overview of available techniques for single-cell analysis by describing the different biological single-cell assays that have been performed to date and how each individual application requires a particular device design.

Graphical abstract: Overview of single-cell analyses: microdevices and applications

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Publication details

The article was received on 28 Jun 2010, accepted on 14 Sep 2010 and first published on 22 Oct 2010


Article type: Critical Review
DOI: 10.1039/C0LC00150C
Citation: Lab Chip, 2010,10, 3363-3372
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    Overview of single-cell analyses: microdevices and applications

    S. Lindström and H. Andersson-Svahn, Lab Chip, 2010, 10, 3363
    DOI: 10.1039/C0LC00150C

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