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Issue 10, 2010
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Chip electrophoresis with mass spectrometric detection in record speed

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Abstract

We demonstrate that the combination of high speed separations on chip with a fast mass spectrometer enables electrophoretic separations with full mass spectra registration within a second. This was accomplished by coupling a microfluidic glass chip with an integrated nanospray emitter to a fast time of flight mass spectrometer working at 100 Hz for data acquisition. Applying field strengths up to 5800 V cm−1 we achieved separations of model analytes such as pharmaceuticals and peptides with subsequent acquisition of full mass spectra within one second or slightly more.

Graphical abstract: Chip electrophoresis with mass spectrometric detection in record speed

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Publication details

The article was received on 06 Jan 2010, accepted on 03 Feb 2010 and first published on 03 Mar 2010


Article type: Paper
DOI: 10.1039/C000349B
Citation: Lab Chip, 2010,10, 1227-1230
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    Chip electrophoresis with mass spectrometric detection in record speed

    S. Fritzsche, P. Hoffmann and D. Belder, Lab Chip, 2010, 10, 1227
    DOI: 10.1039/C000349B

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