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Issue 7, 2010
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Biosensor system-on-a-chip including CMOS-based signal processing circuits and 64 carbon nanotube-based sensors for the detection of a neurotransmitter

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Abstract

We developed a carbon nanotube (CNT)-based biosensor system-on-a-chip (SoC) for the detection of a neurotransmitter. Here, 64 CNT-based sensors were integrated with silicon-based signal processing circuits in a single chip, which was made possible by combining several technological breakthroughs such as efficient signal processing, uniform CNT networks, and biocompatible functionalization of CNT-based sensors. The chip was utilized to detect glutamate, a neurotransmitter, where ammonia, a byproduct of the enzymatic reaction of glutamate and glutamate oxidase on CNT-based sensors, modulated the conductance signals to the CNT-based sensors. This is a major technological advancement in the integration of CNT-based sensors with microelectronics, and this chip can be readily integrated with larger scale lab-on-a-chip (LoC) systems for various applications such as LoC systems for neural networks.

Graphical abstract: Biosensor system-on-a-chip including CMOS-based signal processing circuits and 64 carbon nanotube-based sensors for the detection of a neurotransmitter

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Publication details

The article was received on 17 Aug 2009, accepted on 30 Nov 2009 and first published on 14 Jan 2010


Article type: Paper
DOI: 10.1039/B916975J
Citation: Lab Chip, 2010,10, 894-898
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    Biosensor system-on-a-chip including CMOS-based signal processing circuits and 64 carbon nanotube-based sensors for the detection of a neurotransmitter

    B. Y. Lee, S. M. Seo, D. J. Lee, M. Lee, J. Lee, J. Cheon, E. Cho, H. Lee, I. Chung, Y. J. Park, S. Kim and S. Hong, Lab Chip, 2010, 10, 894
    DOI: 10.1039/B916975J

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