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Issue 38, 2010
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Highly soluble multifunctional MnO nanoparticles for simultaneous optical and MRI imaging and cancer treatment using photodynamic therapy

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Abstract

Superparamagnetic MnO nanoparticles were functionalized using a hydrophilic ligand containing protoporphyrin IX as photosensitizer. By virtue of their magnetic properties these nanoparticles may serve as contrast enhancing agents for magnetic resonance imaging (MRI), while the fluorescent target ligand protoporphyrin IX allows simultaneous tumor detection and treatment by photodynamic therapy (PDT). Caki-1 cells were incubated with these nanoparticles. Subsequent exposure to UV light lead to cell apoptosis due to photoactivation of the photosensitizer conjugated to the nanoparticles. This method offers great diagnostic potential for highly proliferative tissues, including tumors. In addition, it is an efficient platform that combines the advantages of a biocompatible photosensitizer with the possibility for MRI monitoring due to the magnetic properties of the highly soluble functionalized manganese oxide nanoparticles.

Graphical abstract: Highly soluble multifunctional MnO nanoparticles for simultaneous optical and MRI imaging and cancer treatment using photodynamic therapy

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Publication details

The article was received on 16 May 2010, accepted on 20 Jul 2010 and first published on 27 Aug 2010


Article type: Paper
DOI: 10.1039/C0JM01465F
Citation: J. Mater. Chem., 2010,20, 8297-8304
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    Highly soluble multifunctional MnO nanoparticles for simultaneous optical and MRI imaging and cancer treatment using photodynamic therapy

    T. D. Schladt, K. Schneider, M. I. Shukoor, F. Natalio, H. Bauer, M. N. Tahir, S. Weber, L. M. Schreiber, H. C. Schröder, W. E. G. Müller and W. Tremel, J. Mater. Chem., 2010, 20, 8297
    DOI: 10.1039/C0JM01465F

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