Jump to main content
Jump to site search

Issue 42, 2010
Previous Article Next Article

Sol–gel selection of hybrid G-quadruplex architectures from dynamic supramolecular guanosine libraries

Author affiliations

Abstract

We report an original strategy to transcribe and to fix the self-assembly of G-quadruplex architectures in self-organized nanohybrids. In the first resolution step the G-quartet is pre-amplified in solution in the presence of metal cations from a dynamic pool of ribbon-type or cyclic supramolecular architectures. Then in a second selection sol–gel step the G-quadruplex is irreversibly fixed in a siloxane inorganic network. The interface between the guanosine moiety and the heterosiloxane 3 is based on a double reversible covalent iminoboronate connection. This contributes to the high levels of adaptability and correlation in the self-organization of the supramolecular G-quadruplex and the inorganic siloxane systems. Biomimetic-type hybrids can be generated by using this strategy.

Graphical abstract: Sol–gel selection of hybrid G-quadruplex architectures from dynamic supramolecular guanosine libraries

Back to tab navigation

Supplementary files

Publication details

The article was received on 28 Apr 2010, accepted on 02 Jul 2010 and first published on 27 Aug 2010


Article type: Paper
DOI: 10.1039/C0JM01248C
Citation: J. Mater. Chem., 2010,20, 9443-9448
  •   Request permissions

    Sol–gel selection of hybrid G-quadruplex architectures from dynamic supramolecular guanosine libraries

    S. Mihai, Y. Le Duc, D. Cot and M. Barboiu, J. Mater. Chem., 2010, 20, 9443
    DOI: 10.1039/C0JM01248C

Search articles by author

Spotlight

Advertisements