Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance upgrade on Thursday 4th of May 2017 from 8.00am to 9.00am (BST).

During this time our websites will be offline temporarily. If you have any questions please use the feedback button on this page. We apologise for any inconvenience this might cause and thank you for your patience.

Issue 40, 2010
Previous Article Next Article

Design principles for polymers as substratum for adherent cells

Author affiliations


The next generation of biomaterials for regenerative therapies requires the development of substances, which are able to influence and activate specific phenotype characteristics of cells and tissues. Research towards this aim has resulted in an increasing number of reports about material induced cellular functions and cell-cell interactions. In this context, polymeric materials, which are not intended to degrade can provide helpful in-vitro tools to gain more detailed knowledge about the cell-substrate crosstalk and the resulting cell specific effects. This review aims to consolidate current strategies to induce specific effects on adhesive cells which are related to defined characteristics of two-dimensional systems starting with the molecular dimension, following up with the nanostructure and ending with the surface microstructure. This includes approaches to induce direct or indirect biological responses towards cells by systematic changes in material properties such as hydrophilicity or elasticity. These properties are explained as a function of chemical composition such as the type and ratio of copolymers used for linear polymers, or the geometric arrangement of branching points for network polymer architectures. Surface topographical features are identified to strongly influence cell-substrate interactions and techniques are described to control the surface patterning of polymeric materials on the nano- or microscale. Finally we offer a strategy on how to develop complex and multifunctional materials, which might fulfill the requirements of cell and tissue adapted biomaterials for regenerative therapies.

Graphical abstract: Design principles for polymers as substratum for adherent cells

Back to tab navigation
Please wait while Download options loads

Publication details

The article was received on 09 Apr 2010, accepted on 30 Jul 2010 and first published on 24 Aug 2010

Article type: Feature Article
DOI: 10.1039/C0JM00997K
Citation: J. Mater. Chem., 2010,20, 8789-8802
  •   Request permissions

    Design principles for polymers as substratum for adherent cells

    N. Scharnagl, S. Lee, B. Hiebl, A. Sisson and A. Lendlein, J. Mater. Chem., 2010, 20, 8789
    DOI: 10.1039/C0JM00997K

Search articles by author