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Issue 44, 2010
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Carbon nanotube-based magnetic-fluorescent nanohybrids as highly efficient contrast agents for multimodal cellular imaging

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Abstract

We developed a simple and novel layer-by-layer (LBL) assembly in combination with covalent connection strategy for the synthesis of multifunctional carbon nanotubes (CNTs)-based magnetic-fluorescent nanohybrids as multimodal cellular imaging agents for detecting human embryonic kidney (HEK) 293T cells via magnetic resonance (MRI) and confocal fluorescence imaging. Superparamagnetic iron oxide nanoparticles (SPIO) and near-infrared fluorescent CdTe quantum dots (QDs) were covalently coupled on the surface of CNTs in sequence via LBL assembly. It was indicated that the SPIO layer acted not only as a contrast agent for MRI, but also as a spacer between CdTe QDs and CNTs for prohibiting fluorescence quenching of QDs on the surface of the CNTs. The multifunctional CNT-based magnetic-fluorescent nanohybrids showed an enhanced MRI signal as contrast agent for detecting 293T cells in comparison with the pure SPIO. This is due to the magnetic coupling between the orderly arrayed SPIO, the function of CNTs for lowering the transverse relaxation and the ability of CNTs for penetrating into cells. Moreover, the multifunctional CNT-based magnetic-fluorescent nanohybrids exhibited the higher intracellular labeling efficiency due to the ability of CNTs for penetrating into cells in comparison with pure SPIO-CdTe nanoparticles.

Graphical abstract: Carbon nanotube-based magnetic-fluorescent nanohybrids as highly efficient contrast agents for multimodal cellular imaging

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Publication details

The article was received on 03 Mar 2010, accepted on 19 Jul 2010 and first published on 14 Sep 2010


Article type: Paper
DOI: 10.1039/C0JM00594K
Citation: J. Mater. Chem., 2010,20, 9895-9902
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    Carbon nanotube-based magnetic-fluorescent nanohybrids as highly efficient contrast agents for multimodal cellular imaging

    B. Chen, H. Zhang, C. Zhai, N. Du, C. Sun, J. Xue, D. Yang, H. Huang, B. Zhang, Q. Xie and Y. Wu, J. Mater. Chem., 2010, 20, 9895
    DOI: 10.1039/C0JM00594K

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