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Issue 8, 2010
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Fluorescent nanoparticles for ratiometric pH-monitoring in the neutral range

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Abstract

This article describes the synthesis and characterisation of poly(acrylamide) nanoparticles (NPs) with a covalently immobilised pH-sensitive fluorophore. With a pKa of 6.7, good photostability, emission in the visible spectral range and large Stokes' shift the naphthalimide-based pH-indicator is well suited for bio-analytical applications. Additionally, the nanosensors contain a pH-insensitive reference fluorophore that allows the ratiometric monitoring of pH e.g. inside living cells. In order to enhance the cellular uptake and endosomal escape of the beads, novel core–shell nanoparticles bearing a positive ζ-potential are synthesised and evaluated.

Graphical abstract: Fluorescent nanoparticles for ratiometric pH-monitoring in the neutral range

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Publication details

The article was received on 04 Sep 2009, accepted on 27 Nov 2009 and first published on 05 Jan 2010


Article type: Paper
DOI: 10.1039/B918427A
Citation: J. Mater. Chem., 2010,20, 1475-1482
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    Fluorescent nanoparticles for ratiometric pH-monitoring in the neutral range

    A. Schulz, J. Wotschadlo, T. Heinze and G. J. Mohr, J. Mater. Chem., 2010, 20, 1475
    DOI: 10.1039/B918427A

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