Complete separation of magnetic nanoparticles via chemical cleavage of dextran by ethylenediamine for intracellular uptake

Meng Meng Lin; Shanghua Li; Hyung-Hwan Kim; Hyuck Kim; Hyung Bock Lee; Mamoun Muhammed; Do Kyung Kim

doi:10.1039/B918416C

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Journal of Materials Chemistry

Issue 3, 2010

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Complete separation of magnetic nanoparticles via chemical cleavage of dextran by ethylenediamine for intracellular uptake

Meng Meng Lin , Shanghua Li , Hyung-Hwan Kim , Hyuck Kim , Hyung Bock Lee , Mamoun Muhammed and Do Kyung Kim

J. Mater. Chem., 2010, 20, 444-447

DOI: 10.1039/B918416C
Received 08 Sep 2009, Accepted 28 Oct 2009
First published on the web 11 Nov 2009

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Completely water dispersible and highly monodispersed superparamagnetic iron oxide nanoparticles (SPIONs) were prepared. The surface of SPIONs was modified with dual-crosslinked amine activated dextran (AMD) and chemical cleavage of AMD on SPIONs was carried out by ethylenediamine hydrochloride (EDA). Transmission electron microscopy (TEM) revealed that individual SPIONs were completely separated in water and the average diameter of resulting nanoparticles was 4.4 nm.

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Meng Meng Lin
Shanghua Li
Hyung-Hwan Kim
Hyuck Kim
Hyung Bock Lee
Mamoun Muhammed
Do Kyung Kim

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Journal of Materials Chemistry

Complete separation of magnetic nanoparticles via chemical cleavage of dextran by ethylenediamine for intracellular uptake

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