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Issue 5, 2010
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Mussel-inspired molecularly imprinted polymer coating superparamagnetic nanoparticles for protein recognition

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Abstract

In this work, we report a facile approach for imprinting protein based on self-polymerization of dopamine in the presence of template protein on the Fe3O4 nanoparticles (NPs) surface. Dopamine, commonly known as a neurotransmitter, is also a small-molecule mimic of the adhesive proteins of mussels. Self-polymerization of dopamine can produce a thin polydopamine (PDA) layer on Fe3O4 NPs surface. During the self-polymerization of dopamine, some template protein molecules were embedded in the PDA layer. After the removal of these embedded protein molecules, the protein imprinted sites are created. The prepared imprinted Fe3O4@PDA NPs shows high binding capacity and acceptable specific recognition behavior towards template proteins.

Graphical abstract: Mussel-inspired molecularly imprinted polymer coating superparamagnetic nanoparticles for protein recognition

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Publication details

The article was received on 13 Aug 2009, accepted on 29 Oct 2009 and first published on 07 Dec 2009


Article type: Paper
DOI: 10.1039/B916619J
Citation: J. Mater. Chem., 2010,20, 880-883
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    Mussel-inspired molecularly imprinted polymer coating superparamagnetic nanoparticles for protein recognition

    W. Zhou, C. Lu, X. Guo, F. Chen, H. Yang and X. Wang, J. Mater. Chem., 2010, 20, 880
    DOI: 10.1039/B916619J

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