Issue 47, 2010
From the journal:

Journal of Materials Chemistry

Efficient gene delivery with paclitaxel-loaded DNA-hybrid polyplexes based on cationic polyhedral oligomeric silsesquioxanes†

Xian Jun Loh,*a   Zhong-Xing Zhang,a   Khine Yi Mya,a   Yun-long Wu,b   Chao Bin Hea  and  Jun Li*ab  

* Corresponding authors

a Institute of Materials Research and Engineering (IMRE), A*STAR (Agency for Science, Technology and Research), 3 Research Link, Singapore, Singapore
E-mail: XianJun_Loh@scholars.a-star.edu.sg, bielj@nus.edu.sg

b Division of Bioengineering, Faculty of Engineering, National University of Singapore (NUS), 7 Engineering Drive 1, Singapore, Singapore

Abstract

We present a novel hybrid cationic polymer based on polyhedral oligomeric silsesquioxanes (POSS). This is the first report of using a cationic POSS-based material for gene delivery. Due to its amphiphilic properties, hydrophobic drugs such as paclitaxel can be encapsulated within the hydrophobic core of this polymer. In this paper, it is shown that paclitaxel-encapsulated hybrid POSS-based polyplexes show superior gene transfection efficiency in human breast cancer cells than the non drug-loaded polyplexes.

Graphical abstract: Efficient gene delivery with paclitaxel-loaded DNA-hybrid polyplexes based on cationic polyhedral oligomeric silsesquioxanes

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Article information

DOI
https://doi.org/10.1039/C0JM01461C
Article type
Paper
Submitted
15 May 2010
Accepted
01 Aug 2010
First published
04 Oct 2010

J. Mater. Chem., 2010,20, 10634-10642

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Efficient gene delivery with paclitaxel-loaded DNA-hybrid polyplexes based on cationic polyhedral oligomeric silsesquioxanes

X. J. Loh, Z. Zhang, K. Y. Mya, Y. Wu, C. B. He and J. Li, J. Mater. Chem., 2010, 20, 10634 DOI: 10.1039/C0JM01461C

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