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Issue 47, 2010
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Efficient gene delivery with paclitaxel-loaded DNA-hybrid polyplexes based on cationic polyhedral oligomeric silsesquioxanes

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Abstract

We present a novel hybrid cationic polymer based on polyhedral oligomeric silsesquioxanes (POSS). This is the first report of using a cationic POSS-based material for gene delivery. Due to its amphiphilic properties, hydrophobic drugs such as paclitaxel can be encapsulated within the hydrophobic core of this polymer. In this paper, it is shown that paclitaxel-encapsulated hybrid POSS-based polyplexes show superior gene transfection efficiency in human breast cancer cells than the non drug-loaded polyplexes.

Graphical abstract: Efficient gene delivery with paclitaxel-loaded DNA-hybrid polyplexes based on cationic polyhedral oligomeric silsesquioxanes

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Publication details

The article was received on 15 May 2010, accepted on 01 Aug 2010 and first published on 04 Oct 2010


Article type: Paper
DOI: 10.1039/C0JM01461C
Citation: J. Mater. Chem., 2010,20, 10634-10642
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    Efficient gene delivery with paclitaxel-loaded DNA-hybrid polyplexes based on cationic polyhedral oligomeric silsesquioxanes

    X. J. Loh, Z. Zhang, K. Y. Mya, Y. Wu, C. B. He and J. Li, J. Mater. Chem., 2010, 20, 10634
    DOI: 10.1039/C0JM01461C

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