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Issue 16, 2010
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Cellular interactions of biodegradable nanorod arrays prepared by nondestructive extraction from nanoporous alumina

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Abstract

Biodegradable extracellular matrices (ECMs) consisting of mechanically stable arrays of aligned poly(lactide) nanorods (nanorod diameter ≈ 200 nm; lattice constant ≈ 500 nm) with areas up to 9 cm2 were prepared by nondestructive extraction from recyclable self-ordered nanoporous alumina hard templates. Fibroblasts formed dense tissue layers on the heparin/gelatin activated nanorod arrays, showed excellent adhesion and exhibited a highly elongated morphology such as in natural tissue. The synthetic approach reported here combining advantages of top-down lithography (well-defined topography) and self-assembly (low costs, high throughput, feature size in the 100 nm range) may yield ECMs for biomedical applications. Remarkably, on microrod arrays with four times larger feature sizes the fibroblasts were significantly less elongated and their proliferation was strongly reduced.

Graphical abstract: Cellular interactions of biodegradable nanorod arrays prepared by nondestructive extraction from nanoporous alumina

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Publication details

The article was received on 15 Dec 2009, accepted on 02 Feb 2010 and first published on 26 Feb 2010


Article type: Paper
DOI: 10.1039/B926432A
Citation: J. Mater. Chem., 2010,20, 3171-3177
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    Cellular interactions of biodegradable nanorod arrays prepared by nondestructive extraction from nanoporous alumina

    S. Grimm, J. Martín, G. Rodriguez, M. Fernández-Gutierrez, K. Mathwig, R. B. Wehrspohn, U. Gösele, J. San Roman, C. Mijangos and M. Steinhart, J. Mater. Chem., 2010, 20, 3171
    DOI: 10.1039/B926432A

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