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Issue 11-12, 2010
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Tools for analyzing cell shape changes during chemotaxis

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Abstract

Chemotaxis refers to the ability of cells to sense the direction of external chemical gradients and respond by migrating towards the source. A thorough understanding of the chemotactic response of amoebae and neutrophils requires careful quantification of the cell shape changes observed during cell movement. The stochastic nature of this response calls for a statistical characterization of cellular morphology and this requires the processing of large data sets. For this reason, automatic image analysis algorithms are highly desirable and are becoming increasingly available. These usually include a combination of techniques from image segmentation, morphological transformations, as well as the incorporation of numerical algorithms and physical models. Here we review recent developments in the tracking and understanding of motile chemotaxing cells, with a particular emphasis on the description of pseudopodial activity in chemotactic Dictyostelium cells.

Graphical abstract: Tools for analyzing cell shape changes during chemotaxis

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Publication details

The article was received on 17 May 2010, accepted on 26 Aug 2010 and first published on 01 Oct 2010


Article type: Review Article
DOI: 10.1039/C0IB00036A
Citation: Integr. Biol., 2010,2, 561-567
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    Tools for analyzing cell shape changes during chemotaxis

    Y. Xiong and P. A. Iglesias, Integr. Biol., 2010, 2, 561
    DOI: 10.1039/C0IB00036A

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