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Issue 7-8, 2010
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Homing peptides as targeted delivery vehicles

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Abstract

Each normal organ and pathological condition appear to contain organ- or disease-specific molecular tags on its vasculature, which constitute a vascular “zip code” system. In vivo phage display has been exploited to profile this vascular heterogeneity and a number of peptides that home specifically to various normal organs or pathological conditions have been identified. These peptides have been used for targeted delivery of oligonucleotides, drugs, imaging agents, inorganic nanoparticles, liposomes, and viruses. Identification of the receptor molecules for the homing peptides has revealed novel biomarkers for target organs. In tumors many of these receptors seem to play a functional role in tumor angiogenesis. Recently, tumor homing peptides have entered clinical trials. Results from several Phase I and II trials have been reported, and a number of trials are currently ongoing or recruiting patients. In these trials no dose-limiting toxicity has occurred and all combinations of peptide-targeted therapies have been well tolerated.

Graphical abstract: Homing peptides as targeted delivery vehicles

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Publication details

The article was received on 11 Mar 2010, accepted on 16 Jun 2010 and first published on 26 Jul 2010


Article type: Critical Review
DOI: 10.1039/C0IB00013B
Citation: Integr. Biol., 2010,2, 326-337
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    Homing peptides as targeted delivery vehicles

    P. Laakkonen and K. Vuorinen, Integr. Biol., 2010, 2, 326
    DOI: 10.1039/C0IB00013B

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