Issue 8, 2010
From the journal:

Green Chemistry

Green alcohol couplings without transition metal catalysts: base-mediated β-alkylation of alcohols in aerobic conditions†

Laura J. Allena  and  Robert H. Crabtree*a  

* Corresponding authors

a Yale Chemistry Department, 225 Prospect St., New Haven, CT, USA
E-mail: robert.crabtree@yale.edu
Fax: +1 203 432 6144
Tel: +1 203 432 3915

Abstract

Benzylic secondary alcohols can be alkylated in good yields at the β-position with primary alcohols promoted by KOH and NaOH, eliminating the need for toxic and expensive transition metal catalysts.

Graphical abstract: Green alcohol couplings without transition metal catalysts: base-mediated β-alkylation of alcohols in aerobic conditions

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C0GC00079E
Article type
Communication
Submitted
04 May 2010
Accepted
15 Jun 2010
First published
29 Jun 2010

Green Chem., 2010,12, 1362-1364

Permissions

Request permissions

Green alcohol couplings without transition metal catalysts: base-mediated β-alkylation of alcohols in aerobic conditions

L. J. Allen and R. H. Crabtree, Green Chem., 2010, 12, 1362 DOI: 10.1039/C0GC00079E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements