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Issue 5, 2010
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Efficient nitrile hydration mediated by RuII catalysts in micellar media

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Abstract

Efficient nitrile hydration to the corresponding amide derivatives is observed in water using poorly soluble [RuCl26-arene)(PR3)] catalysts 1 with the aid of surfactants to ensure substrate and catalyst solubilization, and enabling ligand effect study on catalytic activity. Amide yields of 40 to 95% can be observed with a variety of aromatic and aliphatic nitriles using the optimized catalyst system, [RuCl2(p-cymene)(PPh2OEt)]/Triton X-114. Catalyst separation and recycling is possible.

Graphical abstract: Efficient nitrile hydration mediated by RuII catalysts in micellar media

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Publication details

The article was received on 18 Nov 2009, accepted on 17 Feb 2010 and first published on 16 Mar 2010


Article type: Communication
DOI: 10.1039/B924244A
Citation: Green Chem., 2010,12, 790-794
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    Efficient nitrile hydration mediated by RuII catalysts in micellar media

    A. Cavarzan, A. Scarso and G. Strukul, Green Chem., 2010, 12, 790
    DOI: 10.1039/B924244A

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