Jump to main content
Jump to site search

Issue 5, 2010
Previous Article Next Article

Advances in the methodology of a multicomponent synthesis of arylnaphthalene lactones

Author affiliations

Abstract

Material and energy inefficiencies in total synthesis can arise from a lack of step economy. Multicomponent syntheses have the potential to optimize step economy and, in turn, to minimize not only waste, but also exposure to hazardous chemicals. Therefore, multicomponent syntheses are of immense interest to the field of Green Chemistry. Herein is described a multicomponent synthesis of arylnaphthalene lignan lactones, which are valuable natural products with promising anticancer and antiviral properties. In an effort to improve our previously reported one-pot, multicomponent synthesis an approach using phenylacetylene, phenylpropargyl chloride, carbon dioxide, catalytic silver iodide, and catalytic 18-crown-6 ether was developed. This methodology was then successfully applied to the preparation of dehydrodimethylconidendrin and its regioisomer, dehydrodimethylretroconidendrin.

Graphical abstract: Advances in the methodology of a multicomponent synthesis of arylnaphthalene lactones

Back to tab navigation

Supplementary files

Publication details

The article was received on 09 Jul 2009, accepted on 19 Feb 2010 and first published on 29 Mar 2010


Article type: Paper
DOI: 10.1039/B913685A
Citation: Green Chem., 2010,12, 888-892
  •   Request permissions

    Advances in the methodology of a multicomponent synthesis of arylnaphthalene lactones

    P. Foley, N. Eghbali and P. T. Anastas, Green Chem., 2010, 12, 888
    DOI: 10.1039/B913685A

Search articles by author

Spotlight

Advertisements