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Issue 2, 2010
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Screening of new solvents for artemisinin extraction process using ab initio methodology

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Abstract

The solubility of artemisinin in a range of conventional and novel solvents was evaluated using the COSMO-RS approach, and verified experimentally as well as against literature data. The computational method was improved by calibrating against a limited set of experimental data, enhancing the accuracy of the calculations. The optimised method was shown to be in reasonable agreement with experimental data; however, lack of reliable experimental data is identified as an issue. Several novel solvents perceived as green alternatives to conventional solvents were targeted and shown to offer good solubility of artemisinin. Extraction from Artemisia annua by carbonate solvents was experimentally verified.

Graphical abstract: Screening of new solvents for artemisinin extraction process using ab initio methodology

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Publication details

The article was received on 23 Oct 2009, accepted on 28 Oct 2009 and first published on 30 Nov 2009


Article type: Paper
DOI: 10.1039/B922001A
Citation: Green Chem., 2010,12, 241-251
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    Screening of new solvents for artemisinin extraction process using ab initio methodology

    A. A. Lapkin, M. Peters, L. Greiner, S. Chemat, K. Leonhard, M. A. Liauw and W. Leitner, Green Chem., 2010, 12, 241
    DOI: 10.1039/B922001A

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