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Issue 42, 2010
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Coordination chemistry of amide-functionalised tetraazamacrocycles: structural, relaxometric and cytotoxicity studies

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Abstract

Three different tetraazamacrocyclic ligands containing four amide substituents that feature groups (namely allyl, styryl and propargyl groups) suitable for polymerisation have been synthesised. Gadolinium(III) complexes of these three ligands have been prepared as potential monomers for the synthesis of polymeric MRI contrast agents. To assess the potential of these monomers as MRI contrast agents, their relaxation enhancement properties and cytotoxicity have been determined. A europium(III) complex of one of these ligands (with propargyl substituents) is also presented together with its PARACEST properties. In addition, to gain further insight into the coordination chemistry of the tetra-propargyl substituted ligand, the corresponding zinc(II) and cadmium(II) complexes have been prepared. The X-ray crystal structures of the tetra-propargyl ligand and its corresponding gadolinium(III), zinc(II) and cadmium(II) complexes are also presented.

Graphical abstract: Coordination chemistry of amide-functionalised tetraazamacrocycles: structural, relaxometric and cytotoxicity studies

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Publication details

The article was received on 09 Jul 2010, accepted on 29 Jul 2010 and first published on 28 Sep 2010


Article type: Paper
DOI: 10.1039/C0DT00815J
Citation: Dalton Trans., 2010,39, 10056-10067
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    Coordination chemistry of amide-functionalised tetraazamacrocycles: structural, relaxometric and cytotoxicity studies

    J. Martinelli, B. Balali-Mood, R. Panizzo, M. F. Lythgoe, A. J. P. White, P. Ferretti, J. H. G. Steinke and R. Vilar, Dalton Trans., 2010, 39, 10056
    DOI: 10.1039/C0DT00815J

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