Asymmetric general base catalysis of the phospho-aldol reaction via dimeric aluminium hydroxides

Abstract

Dimeric aluminium hydroxide complexes containing the (R,R)-N,N′-bis(2′-hydroxy-3′-organobenzyl)-trans-1,2-diaminocyclohexane ligand backbone effect catalysis of the phospho-aldol reaction under ambient, aerobic conditions at catalyst loadings of 0.5 mol% to afford enantioselectivities of ca. 65%.