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Issue 37, 2010
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Calcium binding environments probed by 43Ca NMR spectroscopy

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Abstract

Calcium is an important component of materials, metalloproteins, minerals, glasses, and small inorganic and organic complexes. However, NMR spectroscopy of the quadrupolar 43Ca nuclide remains difficult primarily due to its low natural abundance and low resonance frequency. In this Perspective, experimental challenges and recent successes in the field are highlighted, with a focus on solid-state 43Ca NMR spectroscopy. Solution 43Ca NMR studies of calcium-binding biomolecules are also presented. The structural insights afforded from quadrupolar and chemical shift parameters are examined. For example: isotropic chemical shifts have been shown to correlate with the mean Ca–O distance and also with calcium coordination number; quadrupolar coupling constants and chemical shift tensor spans have been shown to be useful probes of polymorphism; and, distance measurements involving 43Ca have been recently demonstrated. Lastly, challenges and opportunities for the future are considered.

Graphical abstract: Calcium binding environments probed by 43Ca NMR spectroscopy

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Publication details

The article was received on 03 May 2010, accepted on 26 May 2010 and first published on 24 Jun 2010


Article type: Perspective
DOI: 10.1039/C0DT00416B
Citation: Dalton Trans., 2010,39, 8593-8602
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    Calcium binding environments probed by 43Ca NMR spectroscopy

    D. L. Bryce, Dalton Trans., 2010, 39, 8593
    DOI: 10.1039/C0DT00416B

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