Jump to main content
Jump to site search

Issue 35, 2010
Previous Article Next Article

DNA cleavage by the Cu(II) complex of the DNA-intercalating 9-bis(pyridin-2-ylmethyl)aminobenzo[b]quinolizinium

Author affiliations

Abstract

The synthesis and the investigation of the Cu(II)-binding, the DNA-binding, and the DNA-damaging properties of a conjugate between the benzo[b]quinolizinium ion and the bis(pyridin-2-ylmethyl)amino receptor are presented. Photometric and fluorimetric titrations as well as CD spectroscopic analysis reveal that the 9-bis(pyridin-2-ylmethyl)aminobenzo[b]quinolizinium ligand intercalates into DNA (Kb = 1.9 × 104 M−1) and exhibits a high selectivity towards complexation of Cu2+ in water (Kb = 4.3 × 104 M−1). This combination of functionalities allows to localize Cu2+ in close proximity of DNA, where these metal ions induce efficient DNA damage, as shown by the single-strand cleavage of supercoiled plasmid DNA. Notably, the DNA cleavage does not require additional reagents nor light.

Graphical abstract: DNA cleavage by the Cu(ii) complex of the DNA-intercalating 9-bis(pyridin-2-ylmethyl)aminobenzo[b]quinolizinium

Back to tab navigation

Supplementary files

Publication details

The article was received on 31 Mar 2010, accepted on 17 Jun 2010 and first published on 04 Aug 2010


Article type: Paper
DOI: 10.1039/C0DT00238K
Citation: Dalton Trans., 2010,39, 8195-8202
  •   Request permissions

    DNA cleavage by the Cu(II) complex of the DNA-intercalating 9-bis(pyridin-2-ylmethyl)aminobenzo[b]quinolizinium

    M. Tian, H. Ihmels and E. Brötz, Dalton Trans., 2010, 39, 8195
    DOI: 10.1039/C0DT00238K

Search articles by author

Spotlight

Advertisements