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Issue 24, 2010
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Synthesis and characterization of dinuclear heterometallic lanthanide complexes exhibiting MRI and luminescence response

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Abstract

A molecule bearing a macrocyclic DOTA-type chelator and an acyclic chelator based on the 5-aminoisophthalamide diethylenediaminetetraacid (5A-PADDTA) was synthesized by linking these two moieties via an amide bond. The ligand has the possibility to complex two identical or different lanthanide ions, depending on the desire for its potential application. Luminescence studies involving titrations of the Eu3+ or Gd3+ complex with Tb3+ confirm the formation of heterometallic complexes, as well as the presence of different species in the solution. Comparative 1H NMR spectra of the ligand, its Eu3+ complex, and that containing both Eu3+ and Tb3+ proves the existence of respective monometallic or bimetallic species. NMR diffusion measurements on 5A-PADDTA as a model compound indicate the formation of aggregates upon the addition of Y3+ (chosen as a diamagnetic analogue of lanthanide ions). Hydration values were calculated from the respective luminescence lifetime values. They show the dominance of a q = 1 species for both ions in monometallic complexes, or q = 1 and q = 2 species of ions in aggregated complexes, for DOTA and 5A-PADDTA chelators, respectively.

Graphical abstract: Synthesis and characterization of dinuclear heterometallic lanthanide complexes exhibiting MRI and luminescence response

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Publication details

The article was received on 03 Dec 2009, accepted on 20 Apr 2010 and first published on 19 May 2010


Article type: Paper
DOI: 10.1039/B925556G
Citation: Dalton Trans., 2010,39, 5721-5727
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    Synthesis and characterization of dinuclear heterometallic lanthanide complexes exhibiting MRI and luminescence response

    I. Mamedov, T. N. Parac-Vogt, N. K. Logothetis and G. Angelovski, Dalton Trans., 2010, 39, 5721
    DOI: 10.1039/B925556G

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