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Issue 15, 2010
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Bis(thiosemicarbazones) as bifunctional chelators for the room temperature 64-copper labeling of peptides

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Abstract

A range of new carboxylate functionalised bis(thiosemicarbazone) ligands and their Cu(II) complexes have been prepared, fully characterised and radiolabeled in high yield with both 64Cu and 99mTc. Conjugation to a bombesin derivative was achieved using standard solid phase synthetic methodologies and the 64Cu-labeled conjugate was shown to have good tumour uptake in mice with xenografted PC-3 tumours.

Graphical abstract: Bis(thiosemicarbazones) as bifunctional chelators for the room temperature 64-copper labeling of peptides

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Publication details

The article was received on 02 Dec 2009, accepted on 28 Jan 2010 and first published on 03 Mar 2010


Article type: Paper
DOI: 10.1039/B925128F
Citation: Dalton Trans., 2010,39, 3620-3632
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    Bis(thiosemicarbazones) as bifunctional chelators for the room temperature 64-copper labeling of peptides

    R. Hueting, M. Christlieb, J. R. Dilworth, E. G. Garayoa, V. Gouverneur, M. W. Jones, V. Maes, R. Schibli, X. Sun and D. A. Tourwé, Dalton Trans., 2010, 39, 3620
    DOI: 10.1039/B925128F

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