Densely packed Gd(III)-chelates with fast water exchange on a calix[4]arene scaffold: a potential MRI contrast agent

Daniel T. Schühle; Miloslav Polášek; Ivan Lukeš; Thomas Chauvin; Éva Tóth; Jürgen Schatz; Ulf Hanefeld; Marc C. A. Stuart; Joop A. Peters

doi:10.1039/B917673J

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Dalton Transactions

Issue 1, 2010

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Densely packed Gd(III)-chelates with fast water exchange on a calix[4]arene scaffold: a potential MRI contrast agent

Daniel T. Schühle , Miloslav Polášek , Ivan Lukeš , Thomas Chauvin , Éva Tóth , Jürgen Schatz , Ulf Hanefeld , Marc C. A. Stuart and Joop A. Peters

Dalton Trans., 2010, 39, 185-191

DOI: 10.1039/B917673J
Received 27 Aug 2009, Accepted 01 Oct 2009
First published on the web 26 Oct 2009

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A pyridine-N-oxide functionalized DOTA analogue has been conjugated to a calix[4]arene and the corresponding Gd-complex was characterized with respect to its suitability as MRI contrast agent. The compound forms spherical micelles in water with a cmc of 35 μM and a radius of 8.2 nm. The relaxivity of these aggregates is 31.2 s⁻¹ mM⁻¹ at 25 °C and 20 MHz, which corresponds to a molecular relaxivity of 125 s⁻¹ mM⁻¹. The high relaxivity mainly originates from the short τ_M (72.7 ns) and the size of the micelles. The interaction with bovine serum albumin (BSA) was studied and an observed relaxivity of up to 40.8 s⁻¹ mM⁻¹ (163.2 s⁻¹ mM⁻¹ per binding place) at 20 MHz and 37 °C was found in the presence of 2.0 mM protein.

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Daniel T. Schühle
Miloslav Polášek
Ivan Lukeš
Thomas Chauvin
Éva Tóth
Jürgen Schatz
Ulf Hanefeld
Marc C. A. Stuart
Joop A. Peters

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Dalton Transactions

Densely packed Gd(III)-chelates with fast water exchange on a calix[4]arene scaffold: a potential MRI contrast agent

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